Why New Drugs Fail?
According to current data average time and cost of a new drug to reach the market is 12 years and costs £1.15 billion but what is not included in this…
Continue readingClinical Research Review
Innovative Clinical Trial Designs: Overview
Those who have worked on clinical trials for many years probably remember the rigidity of the clinical protocols and how often clinicians complained that the study design is out of…
Continue readingIs Clinical Trial Design Fit for Purpose?
It is not a secret that the research and development in the pharmaceutical industry is very costly, time-consuming, risky and not particularly efficient. According to estimates bringing new drugs on…
Continue readingCAR T Cells and the future of HIV therapy
Chimeric antigen receptor (CAR) T cells have been studied for over 25 years and are very successful in some types of cancer. With more than 30 million people living with…
Continue readingClinical Trial Design and Patients with Brain Metastases from Solid Tumours
The most common spread of metastatic solid tumours in central nerve system (CNS) is as parenchymal brain metastases or as leptomeningeal disease (metastases in brain membrane or spinal cord). Because…
Continue readingB Cell Receptor Targeting and Cancer Therapy
B cell receptor is involved in the normal B cell development and immunity but also in supporting the growth and survival of malignant B cells in patients with B cell…
Continue readingDNA Nanorobots and Cancer Treatment
A research team from National Center for Nanoscience and Technology, Beijing, China has reported an interesting and novel approach in targeting tumours. They have constructed autonomous DNA robots which were…
Continue readingCirculating Tumor Cells and Their Future in Oncology Diagnostic
Circulating tumour cells (CTCs) are rare tumor cells that have been investigated for diagnostic, prognosis and predictive biomarkers for different types of cancer. CTCs have been described back in 1869….
Continue readingPaediatrics Clinical Trials: Children Are Not Simply Small Adults
Children often have the same diseases as adults, however many of the approved drugs on the market are not tasted in children. Many rare and serious diseases affecting children have…
Continue readingCircRNA as Cancer Biomarker and Potential Therapeutic Target
Circular RNAs (circRNAs) are class of long, non-coding RNAs, which are very tissue specific. Initially these circRNAs were thought to have no biological function. In the recent research there are…
Continue reading