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Clinical trial design and patients with brain metastases
The most common spread of metastatic solid tumours in central nerve system (CNS) is as parenchymal brain metastases or as leptomeningeal disease (metastases in brain membrane or spinal cord). Because the brain is protected by blood-brain barrier many drugs in standard...
B cell receptor targeting and cancer therapy
B cell receptor is involved in the normal B cell development and immunity but also in supporting the growth and survival of malignant B cells in patients with B cell leukaemias or lymphomas. The expression of this receptor on the surface of the B cells is important...
DNA nanorobots and cancer treatment
A research team from National Center for Nanoscience and Technology, Beijing, China has reported an interesting and novel approach in targeting tumours. They have constructed autonomous DNA robots which were programmed to transport and deliver therapeutics directly to...
FDA legislation changes and clinical trials: July 2018
FDA extends access to experimental drugs FDA extended access program started back in 2009 and it allowed patients with life-threatening diseases who have exhausted all other options to try experimental drugs, which are not on the market yet. After the implementation...
Circulating tumor cells and their future in oncology diagnostic
Circulating tumour cells (CTCs) are rare tumor cells that have been investigated for diagnostic, prognosis and predictive biomarkers for different types of cancer. CTCs have been described back in 1869. They are not used in clinical practice at the moment, however...
Paediatrics Clinical Trials: Children Are Not Simply Small Adults
Children often have the same diseases as adults, however many of the approved drugs on the market are not tasted in children. Many rare and serious diseases affecting children have no treatment options and as a result clinicians are forced to use “off label” drugs...
CircRNA as cancer biomarker and potential therapeutic target
Circular RNAs (circRNAs) are class of long, non-coding RNAs, which are very tissue specific. Initially these circRNAs were thought to have no biological function. In the recent research there are more and more evidence that these types of RNA are present in mammalian...
Practical Clinical Trials, Issue 4 2017
We are happy to release out annual edition of Practical Clinical Trials magazine for 2017. It features materials which were published on our web site in 2017. It includes some very exciting reviews on latest trends in oncology therapy and diagnostics and lots of...
Practical Clinical Trials Magazine, issue 3 2016
This is the third edition of our free magazine Practical Clinical Trials, which represents articles published in 2016. You can download the magazine here: DOWNLOAD Please follow and like...
White paper: Clinical trials – Recruitment strategies
This white paper is dedicated to one of the clinical research communities’ hot topics – recruitment. We will discuss different recruitment strategies and their advantages and disadvantages from practical point of view and also we hope to give some new ideas for...
Free magazine: Practical Clinical Trials, issue 2 2015
We are happy to present the second edition of our free annual magazine “Practical Clinical Trials”, which contains reviews and analysis on clinical trials set up, SAE reporting, regulatory requirements, etc. Download here Please follow and like...