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How do we know if drugs are carcinogenic?
We often see in the news headlines information of some drug being potentially carcinogenic or contaminated with substance that is potentially carcinogenic. But what that means and how do we test drugs for carcinogenicity? Carcinogenicity testing of substances is...
Is it possible to have an anti-cancer therapeutic vaccine
There are many observations in melanoma lesions where the immune system is able to act against the tumours and usually this is a sign of a good prognosis. However, over time the balance is shifted in favour of the tumours. All this suggests that vaccination for cancer...
The role of microRNAs in human diseases
It is very common that microRNAs are overexpressed or inactivated in human diseases. The best approach in such cases is to either target the overexpressed microRNA to inactivate it or replace the inactive microRNA. But let’s first review what is microRNA and what is...
Could response-based dose be the future of patient care?
FDA report showed that most drugs are effective in only 25-62% of the patients. That probably make you wonder why they are approved and prescribed to patients? The answer to this question is not simple. Many approved drugs have a range of therapeutic dose which could...
Adopting orphan drugs in different therapeutic areas
What happens if a newly developed drug fails in the tested indication? Very often such drugs are abandoned if the developers think they will not be able to be used for different indications or therapeutic areas. In such cases these drugs are classified as ‘orphaned...
Benefits and Challenges of Developing Companion Diagnostics
Personalised medicine is a very popular topic in healthcare as a path towards better and cost-effective treatment of patients. However, we are not there yet due to various reasons. One of the major reasons is lack of diagnostic tests that will equip clinicians with...
Can we predict adverse reactions?
One of the big challenges in drug development is our limited ability to identify potential adverse reactions associated with new therapeutics. Pharmacogenomics provides a great opportunity in understanding the mechanisms of action of drugs and predict not just their...
Practical Clinical Trials, Issue 4 2017
We are happy to release out annual edition of Practical Clinical Trials magazine for 2017. It features materials which were published on our web site in 2017. It includes some very exciting reviews on latest trends in oncology therapy and diagnostics and lots of...
Practical Clinical Trials Magazine, issue 3 2016
This is the third edition of our free magazine Practical Clinical Trials, which represents articles published in 2016. You can download the magazine here: DOWNLOAD
White paper: Clinical trials – Recruitment strategies
This white paper is dedicated to one of the clinical research communities’ hot topics – recruitment. We will discuss different recruitment strategies and their advantages and disadvantages from practical point of view and also we hope to give some new ideas for...
Free magazine: Practical Clinical Trials, issue 2 2015
We are happy to present the second edition of our free annual magazine "Practical Clinical Trials", which contains reviews and analysis on clinical trials set up, SAE reporting, regulatory requirements, etc. Download here [gallery type="slideshow"...
White Paper: Clinical Trials – The Art of Site Management
"Clinical trials monitoring is often considered as limited to therapeutic area knowledge and monitoring experience, ignoring the vital part of the process – the soft skills, or the ability to work with people. Building proper work relationship with healthcare staff...