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Why new drugs fail?
According to current data average time and cost of a new drug to reach the market is 12 years and costs £1.15 billion but what is not included in this statistics is the fact that many new potential drugs never make it to the market due to various reasons. European...
Innovative Clinical Trial Designs: overview
Those who have worked on clinical trials for many years probably remember the rigidity of the clinical protocols and how often clinicians complained that the study design is out of touch with reality. The new tendency of using innovative clinical trial designs shows...
Review: Is clinical trial design fit for purpose?
It is not a secret that the research and development in the pharmaceutical industry is very costly, time-consuming, risky and not particularly efficient. According to estimates bringing new drugs on the market could cost between $800 million and $2 billion. Failure in...
CAR T cells and the future of HIV therapy
Chimeric antigen receptor (CAR) T cells have been studied for over 25 years and are very successful in some types of cancer. With more than 30 million people living with HIV infection there were great hopes that CAR T cells method can help achieve “cure” but...
Clinical trial design and patients with brain metastases
The most common spread of metastatic solid tumours in central nerve system (CNS) is as parenchymal brain metastases or as leptomeningeal disease (metastases in brain membrane or spinal cord). Because the brain is protected by blood-brain barrier many drugs in standard...
B cell receptor targeting and cancer therapy
B cell receptor is involved in the normal B cell development and immunity but also in supporting the growth and survival of malignant B cells in patients with B cell leukaemias or lymphomas. The expression of this receptor on the surface of the B cells is important...
DNA nanorobots and cancer treatment
A research team from National Center for Nanoscience and Technology, Beijing, China has reported an interesting and novel approach in targeting tumours. They have constructed autonomous DNA robots which were programmed to transport and deliver therapeutics directly to...
Practical Clinical Trials, Issue 4 2017
We are happy to release out annual edition of Practical Clinical Trials magazine for 2017. It features materials which were published on our web site in 2017. It includes some very exciting reviews on latest trends in oncology therapy and diagnostics and lots of...
Practical Clinical Trials Magazine, issue 3 2016
This is the third edition of our free magazine Practical Clinical Trials, which represents articles published in 2016. You can download the magazine here: DOWNLOAD Please follow and like...
White paper: Clinical trials – Recruitment strategies
This white paper is dedicated to one of the clinical research communities’ hot topics – recruitment. We will discuss different recruitment strategies and their advantages and disadvantages from practical point of view and also we hope to give some new ideas for...
Free magazine: Practical Clinical Trials, issue 2 2015
We are happy to present the second edition of our free annual magazine “Practical Clinical Trials”, which contains reviews and analysis on clinical trials set up, SAE reporting, regulatory requirements, etc. Download here Please follow and like...