Assessment of Clinical Response
According to statistics back in 2012 there were approximately 981 drugs in development for cancer and this statistic is probably higher now. Some of the main challenges are how to…
Continue readingClinical Research Review
Pharmacokinetics and Pharmacodynamics of Anticancer Drugs
In order to identify the correct dose of any therapeutic agent there are 2 pharmacological phases: Pharmacokinetic phase in which the dose, dosage form, frequency, and route of administration are…
Continue readingTumours and immune system
Tumours crate environment in which all cells are involved in supporting tumour progression. The formation of tumour cell takes many years during which the cell generate transformation that will allow…
Continue readingAre there universal tumour-associated T cell epitomes?
T cell-directed cytokine therapy has shown very promising results in some patients with leukaemia. These results in combination with some animal model data gives a big hope that T cells…
Continue readingWebinar: Do Medical Devices Need Testing
I have been invited to prepare a series of webinars on medical devices and different technologies used in clinical trials. This is the first session that I will be hosting…
Continue readingAntisense Therapies For Cancer
During the recent years scientists have discovered more details about cellular genomes, gene mutations and mechanisms involved in cancer development and spreading. This led to hopes that soon there will…
Continue readingHow Do We Know if Drugs Are Carcinogenic?
We often see in the news headlines information of some drug being potentially carcinogenic or contaminated with substance that is potentially carcinogenic. But what that means and how do we…
Continue readingIs It Possible to Have an Anti – Cancer Therapeutic Vaccine?
There are many observations in melanoma lesions where the immune system is able to act against the tumours and usually this is a sign of a good prognosis. However, over…
Continue readingThe Role of MicroRNAs in Human Diseases
It is very common that microRNAs are overexpressed or inactivated in human diseases. The best approach in such cases is to either target the overexpressed microRNA to inactivate it or…
Continue readingCould Response – Based Dose Be the Future of Patient Care?
FDA report showed that most drugs are effective in only 25-62% of the patients. That probably make you wonder why they are approved and prescribed to patients? The answer to…
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